NP characterisation
In order to assess the biological effects of nanoparticles (NPs)
in experimental exposure studies it is essential to have homogenous
and well-characterised test materials.
There should be uniformity in particle size with minimal batch
variability. To that end, we are collaborating with Dr Paul
Christian at the School of Chemistry, University of Manchester, who
is an expert in the manufacture and characterisation of
nanoparticle materials.
Besides studying commercially available materials, we are
investigating nanoparticles specifically prepared for our research
projects. In those instances, the full characterisation,
preparation and provenance of the material is known.
Our recent studies have used cadmium and silver nanomaterials
prepared by the "arrested precipitation" method. Nanoparticles are
functionalised with a thiolated polyethylene glycol surfactant.
This is not only biologically compatible but is also an excellent
material for maintaining nanoparticles in aqueous suspension of
varying ionic strengths. Such characterisation is not always
available from commercially sourced material.